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Last update: May 2021

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Genetics and Genomics

Subjects of the Genetics and Genomics team

Context and ambition

Feed resources for livestock become increasingly scarce and are subject to competition, especially with food for human consumption. The efficiency with which an animal uses the feed and its ability to adapt to changing feeding conditions are of paramount importance. It is widely acknowledged that these traits, which have been little improved by selection so far, will be potential targets for genomic selection. Detailed phenotyping and high-throughput genotyping now allow for an in-depth analysis of these complex traits.

In this context, our ambition is to describe the genetic architecture of the traits responsible for the development and mobilisation of energy reserves in poultry (chicken and duck) with particular attention for lipid metabolism. Our work focuses on improving additive models for the prediction of the genetic value of breeding stock by taking into account the effects of gene-gene or gene-environment interactions. Our integrative approach allows for the implementation of three complementary methods of analysis: the study of chromosomes locations affecting traits; the study of gene expression at the RNA level; the exploitation of available knowledge on genomes.

Objectives

  • Mapping of genes that affect storage, mobilisation and use of energy reserves in poultry
  • Analysing the genetic regulation of lipid metabolism
  • Participating in the development and refinement of the methods and tools necessary to reach these objectives

Expertise and skills

The GG team has expertise in the different disciplines used for the analysis of traits genetic variability: quantitative and molecular genetics, molecular biology, statistics, bioinformatics and software development.

Methodological skills
  • QTL mapping
  • Analysis of the transcriptome and of its dynamics
  • Gene networks modelling
  • Functional analysis of lipid metabolism
  • Cellular validation of the effects of genomic polymorphisms

People

Members of the Genetics and Genomics team
Resp. GG
Christian Diot

Leader of the "Genetics & Genomics" team

Phone: (+33) 2 23 48 54 61
Mail: Christian Diot

Scientists

Sophie Allais
Nicolas Bédère (cv Hal)
Christian Diot (CV Hal)
Frédéric Hérault (cv Hal)
Sandrine Lagarrigue
Lætitia Lagoutte
Frédéric Lecerf
Pascale Le Roy
Romain Philippe

Technicians
Bénédicte Lebez

PhD students 

Lorry Bécot (subject of thesis)
Fabien Degalez (subject of thesis)
Mathilde Doublet

Formers members
Olivier Demeure
Colette Désert
Olivier Filangi
Jean-Marc Fraslin
Florian Herry (subject of thesis ; PhD defended in 2019)
Frédéric Jehl (subject of thesis ; PhD defended in 2020)
Kévin Muret (PhD defended in 2018)
David Picard-Druet (subject of thesis ; PhD defended in 2020)
Hélène Romé (PhD defended in 2015)
Pierre-François Roux (PhD defended in 2014)
Chaker Sbai

SPACER