Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal


Zone de texte éditable et éditée et rééditée

Jean-Jacques Lareyre

Jean-Jacques Lareyre
© Inra
Physiology of reproduction: gametes production and maturation in male fish

Understanding molecular mechanisms underlying puberty onset in male fish
My current research interests aim to better understand molecular mechanisms underlying the sexual maturation (puberty) in fish, particularly in male. The initiation of the male gametogenesis (spermatogenesis) is an important biological process that impacts puberty onset and ultimately fish fertility. Puberty onset depends on the activation of the gonadotrope axis (GnRHs) that ultimately control the release from the pituitary of two gonadotropins named FSH and LH. Both hormones control the two main testicular functions (spermatogeneis and steroidogenesis). Spermatogeneis relies on the balance between renewal and proliferation/differentiation of germ stem cells. The role of the sexual hormones (gonadotropins and gonadotropin induced sexual steroids) in the regulation of this balance remains poorly understood.

My research is aimed at:

  • characterizing gonadal factors that may be involved in the regulation of germ stem cell fate and/or spermatogonial proliferation in teleost fish species
  • understanding the molecular mechanisms underlying the distinct effects of the sexual hormones (steroids and gonadotropins) on the gonadal functions with a focus on the regulation of testicular factors that regulate the spermatogonial proliferation.

Complementary genomic approaches based on the analysis of transcriptome changes during the testicular maturation and hormonal treatment are conducted in trout (cDNA microarrays, SSH, Q-rtPCR, in situ hybridisation). In silicoanalyses of fish genomes and phylogenetic studies are combined to the transcriptome approaches to understand the conservation and evolutionary changes of the selected genes in different fish orders. We have developed molecular tools to targetin vivogene expression in different cell types of the germinal niche. These studies lead to the production of GFP expressing transgenic lines that will be used to characterize the somatic and the adult germ cell stem cells, to identify new paracrine factors, and to address, in vivo, the functional significance of the selected gonadal factors.

Anterior research
The motility and fertilizing ability of the spermatozoa requires their passage through successive and complex microenvironments provided by different segments of the epididymal duct. My initial research interest was directed towards the understanding of the molecular mechanisms underlying the androgen responsiveness and segment-restricted expression of genes encoding epididymal secretory proteins. Using transient transfection assays, site directed mutagenesis, and in vitro binding studies (EMSA), several functional cis DNA regulatory elements were characterized within the 5' flanking region of the GPX5 and lcn5 genes including androgen receptor responsive elements. In addition, using transgenic mice, we demonstrated that promoter fragments (about 1.8 kb) of the lcn8 and lcn5 genes contained all the information required for the endocrine control and expression of transgene to the proximal (lcn8) and distal caput epididymidis (lcn5) in vivo.


  • Ph.D.: Cellular and Molecular Biology, Blaise Pascal University, Clermont-Ferrand, France (1996)
  • Master: Cellular and Molecular Biology, Blaise Pascal University, Clermont-Ferrand, France (1992)
  • B.Sc.: Mathematics and Biology, Clermont-Ferrand, France (1986)

Employments history

  • 1998- present: Researcher, SCRIBE, Research Unit UR 1037 (SCRIBE), Fish Reproduction research group, Animal Physiology Department, French National Institute for Agricultural Research
  • 1996-1998: Research Associate, Center for Reproductive Biology Research, Departemnt of Obstetrics & Gynecology, Vanderbilt University, Medical School

Administrative responsibilities

  • 2005-present: Co-animator of the "Reproductive Physiology and Environment " working group of the BIOSIT federative research institute

Teaching responsibilities

  • 2007-present: Person in charge of organizing Master courses for the training of agronomist specialized in the management of marine resources


Social media

See also

Research group "Sexual Maturation, Cryoconservation and Regeneration" and Research