Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal


Zone de texte éditable et éditée et rééditée

Catherine Labbé

Catherine Labbé
© Inra
Epigenetic modifications in sperm and embryo in relation with the impact of preservation biotechnologies

The objective of my research is to provide reliable biotechnologies for genome preservation in aquatic species, which embraces the mastering of cell and tissue cryopreservation, and that of fish regeneration from cryopreserved cells. My research is dedicated to understanding whether cryopreservation is at risk to induce epigenetic alteration in the cryopreserved cells, and how the progeny can be affected. I am also studying how the embryo is properly reprogrammed after nuclear transfer, when the epigenetic and cellular profile of the somatic cell is so different from that of the spermatozoa.

My original background is about cell cryopreservation in fish, and the study of the molecular and cellular parameters involved in fish cell capacity to withstand cryopreservation. My group has also developed the hard won nuclear transfer technology, which allows the reconstruction of a fish from a somatic cell when no germ cell is easily available. Based on this experience, we are now studying whether the preservation biotechnologies affect DNA methylation in sperm and embryos, and how we can improve sperm and somatic cell reprogramming ability, either in vitro or within the oocyte. In the MaRé Research group, we also want to establish how the spermatozoa epigenetic profile is set up during gametogenesis, and which environmental and biotechnological factors are at risk to ultimately alter the proper profile in sperm.

Network and projects

I am member of the CRB Anim PIA French project (2013-2019) where I coordinate the work-package on technological improvements for reproductive material. I have been involved in the scientific coordination of several national projects dedicated to genetic resources preservation, including CCRB/IBiSA CRYOAQUA (2009-2011) which triggered the creation of the French Cryobank for Aquatic Resources (CRYOAQUA) near Rennes. In the H2020 European program AQUAEXCEL2020, I am task leader of the cryobanking network within the consortium. I have been actively involved in the COST project AQUAGAMETE (2013-2016), one of our latest achievements being the Aquaculture special issue on Recent Advances in Fish Gamete and Embryo Research (2017) that I have coordinated with Esther Lubzens and Andrzej Ciereszko. I have developed a long lasting collaboration with Marc Suquet (IFREMER), Pierrick Haffray (SYSAAF) and the IMV Technologies company, to set up cryopreservation in new species and cell types. My latest projects are about the interspecific comparison of DNA methylation pattern in sperm, in relation with chromatin organization (SPERMETH, 2017-2019, coord. H. Jammes, INRA), and about the cryopreservation of immature gonads and the consequences on the epigenetic profile of the gametes produced after grafting (BIOGERM, FEAMP, 2018-2020, coord. JJ Lareyre, INRA).


  • 1992: PhD from Rennes 1 University: Biochemical and biophysical characterization of rainbow trout sperm plasma membrane, changes induced by the diet and the rearing temperature. Supervisor: Dr Maurice Loir.
  • 2003: HDR (Habilitation for Research Supervision) from Rennes 1 University: Molecular and Cellular Damages induced by cryopreservation to fish spermatozoa.


  • 1992: Tenured junior researcher (Chargée de Recherche) at the INRA Fish Physiology Lab in Rennes
  • 1994-1995: Visiting research fellow in Dr John Crowe’s group (UC Davis, USA) and in Dr Richard Sleight’s group, (University of Cincinnati, USA): biochemistry and biophysics of the plasma membrane lipids
  • 2010: Leader of the Cryopreservation and regeneration group, INRA Fish Physiology and Genomics Lab in Rennes
  • 2016: Tenured Research Director, Leader of the Sexual Maturation, Cryopreservation and Regeneration (MaRé) group, Deputy Director of the Fish Physiology and Genomics lab.
  • Teaching
  • 1998-2007: Responsible for the teaching unit on Biology and Aquaculture within the master degree “Animal Production” (BAPSA), Rennes 1 University
  • Since 2007: Master course on Cryobiology, Cryopreservation and the regeneration technologies, Rennes 1 University
  • Since 2013: Training School teaching to PhD students within the EU COST AQUAGAMETE project


Social media

See also

Research group "Sexual Maturation, Cryoconservation and Regeneration" and Research