Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Institut Agro Rennes Angers Rennes 1 University Logo Igepp

Home page


Role of epigenetic and tranScripTomIc modifications in inteRspecific hybRids In chaNginG the rules of crossover regulation: the Brassica model


Meiotic recombination is the main mechanism allowing reshuffling the genetic diversity at each generation. It is thus critical to the introduction of genes of interest into crops, and in the process of reducing their environmental footprint, while at the same time maintaining both yield and quality. However, as meiosis is strictly controlled, the introduction of alleles of interest may take a decade and cannot be applied to the genomic regions that are deprived of recombination. Indeed, only one and rarely three crossovers (COs) per homologous chromosomes are formed during meiosis. These COs are not randomly distributed along the chromosomes (mainly in distal regions of the chromosomes). Recently, we showed that it is possible to change drastically both the number and localization of COs through interspecific hybridization and aneuploidy. By crossing the allopolyploid oilseed rape (Brassica napus, AACC, 2n=4x=38) crop with one of its progenitor, B. rapa (AA, 2n=2x=20), we obtained allotriploid hybrids (AAC, 2n=3x=29). In these hybrids, we observed a 3.4x increase of COs number and a modification of the CO landscape with CO formation in normally cold regions (pericentromeres) of the A chromosomes. The mechanisms involved in this modification of meiosis regulation remains totally unknown. In addition, it remains to be deciphered if these modified recombination rules may be maintained or reversed to normal.


The objectives of this project are to answer the following two questions:

1) What is the role of epigenomic/transcriptomic modifications in changing the recombination rules?
To answer this question, we will perform comparative genomic analyses (BS-Seq and RNA-Seq from flower buds) to explore the potential role of DNA methylation and transcriptomic modifications in modifying the recombination rules.

2) Can these modified recombination rules be maintained or reversed back to normal?
To answer this second question, we will combine genetic mapping and immunostaining approaches to determine the fate of this unique recombination pattern in allotriploid progenies.

Results from this project will provide major knowledge highlighting the natural mechanisms involved in meiotic (de)regulation, and will generate a major translational impact by providing novel and effective breeding strategies in a major crop, oilseed rape.